Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations.

@article{Zucchi2012ProgestinsAA,
  title={Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations.},
  author={Sara Zucchi and Sara Castiglioni and Karl Fent},
  journal={Environmental science & technology},
  year={2012},
  volume={46 9},
  pages={5183-92}
}
Progesterone (P4) and synthetic progestins (gestagens) from contraceptives and hormone therapy occur in treated wastewater and surface water, and they may have adverse effects on aquatic organisms. Little is known about the molecular and reproductive effects of P4 and synthetic progestins in fish, and effects of the antiprogestin mifepristone (RU486, an abortive) are unknown. We aimed at elucidating effects on the hormone system by quantitative determination of transcriptional changes of target… CONTINUE READING

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Occurrence of pharmaceuticals and hormones in drinking water treated from surface waters

  • E. Vulliet, C. Cren-Olive, M. F. Grenier-Loustdot
  • Environ . Chem . Lett .
  • 2011

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