Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility.

@article{Maccarrone2001ProgesteroneUA,
  title={Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility.},
  author={Mauro Maccarrone and Herbert Valensise and Monica Bari and Natalia Lazzarin and Carlo Romanini and Alessandro Finazzi-Agr{\`o}},
  journal={Journal of immunology},
  year={2001},
  volume={166 12},
  pages={7183-9}
}
Physiological concentrations of progesterone stimulate the activity of the endocannabinoid-degrading enzyme anandamide hydrolase (fatty acid amide hydrolase, FAAH) in human lymphocytes. At the same concentrations, the membrane-impermeant conjugate of progesterone with BSA was ineffective, suggesting that binding to an intracellular receptor was needed for progesterone activity. Stimulation of FAAH occurred through up-regulation of gene expression at transcriptional and translational level, and… CONTINUE READING

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