Progesterone up-regulates WT1 mRNA and protein, and alters the relative expression of WT1 transcripts in cultured endometrial stromal cells.

@article{Anthony2003ProgesteroneUW,
  title={Progesterone up-regulates WT1 mRNA and protein, and alters the relative expression of WT1 transcripts in cultured endometrial stromal cells.},
  author={Fred Erick W Anthony and D. D. Y. Mukhtar and Melanie A Pickett and Iain T. Cameron},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2003},
  volume={10 8},
  pages={509-16}
}
OBJECTIVE To determine the change in expression of the Wilms tumor suppressor gene product, WT1, by progesterone alone in endometrial stromal cell culture and to study its relationship with prolactin, a marker of decidualization. In addition, to examine the change in ratio of WT1 isoforms with and without exon 5 message. METHODS Endometrial biopsies were taken from eight patients who had hysterectomy. Stromal cells were isolated and cultured in the presence of progesterone alone (12 days) or… CONTINUE READING