Progesterone transcriptionally inhibits LPS-induced matrix metalloproteinase up-regulation in human cervical fibroblast cells

@inproceedings{Kuwabara2014ProgesteroneTI,
  title={Progesterone transcriptionally inhibits LPS-induced matrix metalloproteinase up-regulation in human cervical fibroblast cells},
  author={Yoshimitsu Kuwabara and Akira Katayama and Sachiko Kurihara and Mirei Yonezawa and Nozomi Ouchi and Ryuichi Sawa and Toshiyuki Takeshita},
  year={2014}
}
s for the 29th Annual Congress of Japanese Society / Journal of Reproductive Immunology 106 (2014) 1–20 17 LPS stimulation induced a significant increase of transcript levels of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-9, while P4 treatment significantly attenuated LPSinduced increase of transcript levels of these MMPs. Conclusions: Our preliminary results suggest that P4 might prevent spontaneous preterm labor by inhibiting cervical remodeling, particularly through the attenuation of… CONTINUE READING

Similar Papers

Topics from this paper.