Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability.

@article{Lee2012ProgesteroneST,
  title={Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability.},
  author={Jee Hyung Lee and John P. Lydon and Chang H Kim},
  journal={European journal of immunology},
  year={2012},
  volume={42 10},
  pages={2683-96}
}
While induced FoxP3(+) T cells (iTreg cells) are promising cellular therapeutics to treat inflammatory diseases, a limitation in utilizing iTreg cells prepared in vitro is their low stability in inflammatory conditions. Progesterone (P4) is an immune regulatory nuclear hormone with a potent Treg induction activity. We reasoned that this function of progesterone would be utilized to generate iTreg cells with highly suppressive activity and improved stability in vivo. Here we generated iTreg… CONTINUE READING