Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2.

@article{Pr2003ProgesteroneRI,
  title={Progesterone regulates IL12 expression in pregnancy lymphocytes by inhibiting phospholipase A2.},
  author={Gabriella P{\'a}r and Janos Geli and No{\'e}mi Kozma and P{\'e}ter Varga and J{\'u}lia Szekeres-Barth{\'o}},
  journal={American journal of reproductive immunology},
  year={2003},
  volume={49 1},
  pages={1-5}
}
PROBLEM Progesterone-induced blocking factor (PIBF) is one of the pathways that mediate the immunological effects of progesterone. PIBF inhibits natural killer (NK) cytotoxic activity. Recently we showed that neutralization of PIBF results in an increased interleukin (IL)-12 expression, which is corrected by cyclooxygenase inhibitors. As exogenous… CONTINUE READING