Progesterone receptors in reproduction: functional impact of the A and B isoforms.

@article{Conneely2000ProgesteroneRI,
  title={Progesterone receptors in reproduction: functional impact of the A and B isoforms.},
  author={Orla M. Conneely and John P. Lydon},
  journal={Steroids},
  year={2000},
  volume={65 10-11},
  pages={571-7}
}
Progesterone (P) is a key regulator of female reproductive activity. The effects of P are mediated by two progesterone receptor (PR) proteins, termed A and B, that arise from a single gene and act as ligand-activated transcription factors to regulate the expression of reproductive target genes. Null mutation of the PR gene in mice (PRKO) leads to pleiotropic reproductive abnormalities. This paper will review the reproductive functions of PRs delineated using the PRKO mouse. Further, we will… CONTINUE READING

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