Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies

@article{Johnatty2007ProgesteroneRP,
  title={Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies},
  author={Sharon E Johnatty and Amanda B. Spurdle and Jonathan Beesley and Xiaoqing Chen and John L Hopper and David L Duffy and Georgia Chenevix-Trench and The Kathleen Cuningham Consortium for Research in Fami Cancer},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={109},
  pages={91-99}
}
Association studies aimed at identifying breast cancer susceptibility variants in the progesterone receptor (PGR) gene have been previously reported in the literature with conflicting results, ranging from a protective effect conferred by the PROGINS allele in German Caucasian women, to an increased risk for the leucine variant of the Val660Leu (rs1042838) polymorphism in East Anglian cases. We report the results of genotype and haplotype analyses of five PGR polymorphisms, +44C/T (rs518162… CONTINUE READING
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