Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas.

@article{Brandon1993ProgesteroneRM,
  title={Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas.},
  author={David D. Brandon and Cynthia L Bethea and Estil Y. Strawn and Miles J. Novy and Kenneth A Burry and Martha Harrington and Timothy Erickson and Christy Warner and Edward Keenan and G. Clinton},
  journal={American journal of obstetrics and gynecology},
  year={1993},
  volume={169 1},
  pages={78-85}
}
OBJECTIVE Our purpose was to identify molecular mechanisms underlying abnormal growth of uterine leiomyomas. STUDY DESIGN Biopsy samples of tumor and adjacent "normal" myometrium from nine patients were analyzed for progesterone receptor gene expression and for proliferation-associated antigen Ki-67. RESULTS Northern analysis indicated that progesterone receptor messenger ribonucleic acid levels were increased twofold to 15-fold in leiomyoma compared with adjacent myometrial biopsy tissue… CONTINUE READING

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