Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.

@article{Mir2013ProgesteroneRM,
  title={Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy.},
  author={Shakeel U R Mir and Steven R. Schwarze and Ling Jin and Jinling Zhang and Woodrow Friend and Sumitra Miriyala and Daret K. St. Clair and Rolf Joseph Craven},
  journal={Autophagy},
  year={2013},
  volume={9 10},
  pages={1566-78}
}
Autophagy resembles a recycling process in which proteins, organelles, or regions of the cytoplasm are enveloped and degraded. We have found that two of the central autophagy proteins, MAP1LC3 (microtubule-associated protein 1 light chain 3, also described as LC3) and UVRAG (UV radiation resistance associated/UV radiation associated gene), complex with PGRMC1/S2R (progesterone receptor membrane component 1, also known as sigma-2 receptor). PGRMC1 is a cytochrome that is induced in cancer and is… CONTINUE READING