Progesterone receptor-mediated effects of neuroactive steroids

@article{Rupprecht1993ProgesteroneRE,
  title={Progesterone receptor-mediated effects of neuroactive steroids},
  author={Rainer Rupprecht and Johannes M. H. M. Reul and Thorsten Trapp and Bas van Steensel and Christian H Wetzel and Klaus Damm and Walter Zieglg{\"a}nsberger and Florian Holsboer},
  journal={Neuron},
  year={1993},
  volume={11},
  pages={523-530}
}
Several 3 alpha-hydroxysteroids accumulate in the brain after local synthesis or after metabolization of steroids that are provided by the adrenals. The 3 alpha-hydroxy ring A-reduced pregnane steroids allopregnanolone and tetrahydrodeoxycorticosterone are believed not to interact with intracellular receptors, but enhance GABA-mediated chloride currents. The present study shows that these neuroactive steroids can regulate gene expression via the progesterone receptor. The induction of DNA… Expand
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