Progesterone receptor isoforms and proliferation in the rat mammary gland during development.

@article{Kariagina2007ProgesteroneRI,
  title={Progesterone receptor isoforms and proliferation in the rat mammary gland during development.},
  author={Anastasia Kariagina and Mark D. Aupperlee and Sandra Z. Haslam},
  journal={Endocrinology},
  year={2007},
  volume={148 6},
  pages={2723-36}
}
Progesterone (P), acting through progesterone receptor (PR) isoforms A and B, plays an important role in normal mammary gland development and is implicated in the etiology of breast cancer. Because of significant similarities between human and rat mammary gland development and hormonal responsiveness of mammary cancers, we investigated P action in the rat mammary gland. By immunohistochemical methods we determined PRA and PRB expression at puberty, sexual maturity, pregnancy, and lactation and… CONTINUE READING

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