Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation

@inproceedings{Bertucci2013ProgesteroneRI,
  title={Progesterone receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation},
  author={Paola Y Bertucci and Ana Silvina Nacht and Mariano All{\'o} and Luciana Rocha-Viegas and Cecilia Ballar{\'e} and Daniel Soronellas and Giancarlo Castellano and Roser Zaur{\'i}n and Alberto R. Kornblihtt and Miguel Beato and Guillermo P Vicent and Adal{\'i} Pecci},
  booktitle={Nucleic acids research},
  year={2013}
}
Steroid receptors were classically described for regulating transcription by binding to target gene promoters. However, genome-wide studies reveal that steroid receptors-binding sites are mainly located at intragenic regions. To determine the role of these sites, we examined the effect of progestins on the transcription of the bcl-x gene, where only intragenic progesterone receptor-binding sites (PRbs) were identified. We found that in response to hormone treatment, the PR is recruited to these… CONTINUE READING
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