Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures.

@article{Sriraman2010ProgesteroneRG,
  title={Progesterone receptor-induced gene expression in primary mouse granulosa cell cultures.},
  author={Venkataraman Sriraman and Mala Sinha and Joanne S Richards},
  journal={Biology of reproduction},
  year={2010},
  volume={82 2},
  pages={402-12}
}
The progesterone receptor (PGR) is induced by luteinizing hormone (LH) in granulosa cells of preovulatory follicles, and the PGR-A isoform is essential for ovulation based on the phenotypes of Pgr isoform-specific knockout mice. Although several genes regulated by PGR-A in vivo have been identified, whether these genes are primary targets of PGR-A or if their expression also depends on other signaling molecules that are induced by the LH surge has not been resolved. Therefore, to identify genes… CONTINUE READING

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