Progesterone receptor-estrogen receptor crosstalk: a novel insight.

  title={Progesterone receptor-estrogen receptor crosstalk: a novel insight.},
  author={Christoforos Thomas and Jan-{\aa}ke Gustafsson},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={26 9},
Copy number loss of the PGR gene and decreased expression of progesterone receptor (PR) may account for worse clinical outcomes in some individuals with estrogen receptor α (ERα)-positive breast cancer. A recent report shows that PR activation inhibits estrogen-driven breast tumor growth by altering ERα chromatin binding and transcriptional activity.