Progesterone receptor antagonists and prostaglandins in human fertility regulation: a clinical review.

@article{Healy1990ProgesteroneRA,
  title={Progesterone receptor antagonists and prostaglandins in human fertility regulation: a clinical review.},
  author={D. Healy},
  journal={Reproduction, fertility, and development},
  year={1990},
  volume={2 5},
  pages={
          477-90
        }
}
  • D. Healy
  • Published 1990
  • Biology, Medicine
  • Reproduction, fertility, and development
  • Progesterone receptor antagonists have been developed by substitutions at the 11-beta and 17 side-chain positions of the progestagen norethisterone. The most studied progesterone receptor antagonists are mifepristone (Mifegyne; Roussel-UCLAF; RU486) and ZK98734 and ZK98299 (Schering AG). These compounds bind avidly to the progesterone receptor and glucocorticoid receptor but have essentially no binding to the mineralocortocoid, oestrogen or androgen receptors. Mifepristone also binds avidly to… CONTINUE READING
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    • 1992

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