Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats.

  title={Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats.},
  author={Shaila K. Mani and A J Mitchell and Bert W. O’Malley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 3},
  • S. ManiA. MitchellB. O’Malley
  • Published 30 January 2001
  • Biology, Psychology
  • Proceedings of the National Academy of Sciences of the United States of America
Ovarian steroids, estrogen and progesterone, influence the sensitivity of certain neural processes to cannabinoid treatment by modulation of brain dopaminergic activity. We examined the effects of the active ingredient of cannabis, Delta(9)-tetrahydrocannabinol (THC), on sexual behavior in female rats and its influence on steroid hormone receptors and neurotransmitters in the facilitation of sexual receptivity. Our results revealed that the facilitatory effect of THC was inhibited by… 

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