Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.

@article{Obr2013ProgesteroneRA,
  title={Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.},
  author={Alison E Obr and Sandra L. Grimm and Kathleen A. Bishop and John Wesley Pike and John P. Lydon and Dean P. Edwards},
  journal={Molecular endocrinology},
  year={2013},
  volume={27 11},
  pages={1808-24}
}
Progesterone (P4) stimulates proliferation of the mammary epithelium by a mechanism that involves paracrine signaling mediated from progesterone receptor (PR)-positive to neighboring PR-negative cells. Here we used a primary mouse mammary epithelial cell (MEC) culture system to define the molecular mechanism by which P4 regulates the expression of target gene effectors of proliferation including the paracrine factor receptor and activator of nuclear factor κB ligand (RANKL). MECs from adult… CONTINUE READING