Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.

@article{Ibrahim2008ProgesteroneRR,
  title={Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2.},
  author={Yasir H. Ibrahim and Sara A. Byron and Xiaojiang Cui and Adrian V. Lee and Douglas Yee},
  journal={Molecular cancer research : MCR},
  year={2008},
  volume={6 9},
  pages={1491-8}
}
Progesterone action contributes to the signaling of many growth factor pathways relevant to breast cancer tumor biology, including the insulin-like growth factor (IGF) system. Previous work has shown that insulin receptor substrate-2 (IRS-2) but not IRS-1 levels were regulated by progestin in progesterone receptor-B (PR-B) isoform expressing MCF-7 cells (C4-12 PR-B). Furthermore, type 1 IGF receptor (IGF1R) signaling via IRS-2 correlated with the increased cell migration observed in a number of… CONTINUE READING

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