Progesterone prevents mitochondrial dysfunction in the spinal cord of wobbler mice.

Abstract

In the Wobbler mouse, a mutation of the Vps54 protein increases oxidative stress in spinal motoneurons, associated to toxic levels of nitric oxide and hyperactivity of nitric oxide synthase (NOS). Progesterone neuroprotection has been reported for several CNS diseases, including the Wobbler mouse neurodegeneration. In the present study, we analyzed… (More)
DOI: 10.1111/j.1471-4159.2012.07753.x

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