Progesterone prevents estradiol-induced dendritic spine formation in cultured hippocampal neurons.

@article{Murphy2000ProgesteronePE,
  title={Progesterone prevents estradiol-induced dendritic spine formation in cultured hippocampal neurons.},
  author={Diane D. Murphy and Menahem Segal},
  journal={Neuroendocrinology},
  year={2000},
  volume={72 3},
  pages={133-43}
}
Estradiol has been shown to cause an increase in dendritic spine density in cultured hippocampal neurons, an effect mediated by downregulation of brain-derived neurotrophic factor (BDNF) and glutamic acid decarboxylase (GAD), and the subsequent phosphorylation of cAMP response element binding protein (CREB) in response to enhanced activity levels. Interestingly, progesterone was shown to counteract the effects of estradiol on dendritic spine density in vivo and in vitro. The present study… CONTINUE READING

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