Progesterone pretreatment enhances cellular sensitivity to cadmium despite a marked activation of the metallothionein gene.

@article{Shimada1997ProgesteronePE,
  title={Progesterone pretreatment enhances cellular sensitivity to cadmium despite a marked activation of the metallothionein gene.},
  author={Hiroyasu Shimada and James F Hochadel and Michael P. Waalkes},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={142 1},
  pages={178-85}
}
Previously, we found that in vivo pretreatment with progesterone markedly increased cadmium lethality in rats, apparently by enhancing cadmium-induced hepatonecrosis. Therefore, the present study was designed to investigate this phenomenon at the molecular level in an in vitro system. TRL-1215 rat liver cells were exposed to various concentrations of progesterone (0, 1, 10, and 100 microM) for 24 hr and subsequently exposed to cadmium (0, 1, 5, 10, and 50 microM; as CdCl2) for an additional 24… CONTINUE READING

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