Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB.

@article{Koulen2008ProgesteronePI,
  title={Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB.},
  author={Peter Koulen and Christian Madry and Raymond Scott Duncan and Ji-Yeon Hwang and Everett Nixon and Nathalie McClung and Elaine V Gregg and Meharvan Singh},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2008},
  volume={21 1-3},
  pages={161-72}
}
The activity of cells critically depends on the control of their cytosolic free calcium ion (Ca(2+)) concentration. The objective of the present study was to identify mechanisms of action underlying the control of the gain of intracellular Ca(2+) release by circulating gonadal steroid hormones. Acute stimulation of isolated neurons with progesterone led to IP(3)R-mediated Ca(2+) transients that depend on the activation of the PI3 kinase/Akt/PKB signaling pathway. These results were confirmed at… CONTINUE READING

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