Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat

@article{Hanukoglu1977ProgesteroneMI,
  title={Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat},
  author={Israel Hanukoglu and Harry J. Karavolas and Robert w. Goy},
  journal={Brain Research},
  year={1977},
  volume={125},
  pages={313-324}
}
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Progesterone 5α-reductase in mouse brain
Progesterone metabolism by the hypothalamus, pituitary, and uterus of the rat during pregnancy.
TLDR
It is concluded that there are different profiles in the in vitro metabolism of [3H]progesterone by the hypothalamus, pituitary, and uterus of the rat during the course of pregnancy.
The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex.
TLDR
It is concluded that the pregnanolones have strong antiepileptic properties and the rapid onset of effect indicates that the steroids may interact with the neuronal function at the membrane or synaptic levels.
Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum
Preliminary Note Metabolism of Progesterone in Mouse Brain
TLDR
Comparison of the chromatographic behaviour of the unknown metabolite with that of authentic progesterone derivatives suggested that this metabolite corresponds to 20-hydroxy-4-pre gnene-3-one, and subcellular fractionation of mouse brain demonstrated a particulate location for the 5~-reduction of progester one and a cytosolic location forThe unknown major metabolite.
Metabolism of progesterone in mouse brain
Conversion of 17α-hydroxyprogesterone to 5α, 3α, and 20α-reduced metabolites by female rat anterior pituitary and hypothalamus
Androgens and the Brain: Role of Testosterone Metabolism
TLDR
The brain must be viewed not only as an important target for steroid effects, but also as a structure which possesses the machinery for synthesizing hormone precursors and for metabolizing both these precursor and hormones originating in the peripheral steroidogenetic glands, in order to fulfill specific functional requirements.
Pregnanolone (3α-hydroxy-5α-pregnane-20-one), a progesterone metabolite, facilitates inhibition of synaptic transmission in the Schäffer collateral pathway of the guinea pig hippocampus in vitro
Biosynthesis of androgens by pheochromocytomas
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TLDR
It is suggested that one function of the rat pineal is to serve as a neuroendocrine transducer, which converts a neural input into an endocrine message and influences gonad function.
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In vitro accumulation and saturation of 3H-progestins in selected brain regions and in the adenohypophysis, uterus and pineal of the female rat.
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TLDR
Anterior pituitary glands from diestrous and proestrous rats were incubated with 3H-progesterone and radioactivity extracted was characterized as progesterone, 5α-pregnane- 3,20-dione and 3α-hydroxy-5 α-pregnan-20- one by reverse isotopic dilution.
Uptake of (3H)progesterone and (3H)5alpha-dihydroprogesterone by rat tissues in vivo and analysis of accumulated radioactivity: accumulation of 5alpha-dihydroprogesterone by pituitary and hypothalamic tissues.
TLDR
High and significant amounts of 5alpha-DHP are accumulated in pituitary and hypothalamus, but not in uterus, which suggests that its presence may be functionally important in governing progesterone-sensitive processes in these feedback tissues.
Comparative facilitation and inhibition of lordosis in the guinea pig with progesterone, 5α-pregnane-3,20-dione, or 3α-hydroxy-5α-pregnan-20-one
Sex-Dependent Changes in Pituitary 5α:-Dihydrotestosterone and 3α-Androstanediol Formation During Postnatal Development and Puberty in the Rat
TLDR
At birth, pituitary DHT and DIOL formation was equal in both sexes, but significant sex-specific changes occurred during development, and in females the formation of both metabolites rose dramatically with age to reach a peak value between 10 and 15 days; the latter values exceeded that obtained in adult prostate.
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