Progesterone inhibits rejection of xenogeneic transplants in the sheep uterus.

@article{Majewski2002ProgesteroneIR,
  title={Progesterone inhibits rejection of xenogeneic transplants in the sheep uterus.},
  author={Andrew C Majewski and Peter J. Hansen},
  journal={Hormone research},
  year={2002},
  volume={58 3},
  pages={
          128-35
        }
}
OBJECTIVES One of the proposed roles of progesterone is to prevent maternal immunological destruction of the allogeneic conceptus. Here, it was demonstrated that progesterone allows survival of a xenotransplant placed in the uterine lumen. METHODS Ovariectomized ewes, surgically prepared to have ligatures around each uterine horn, were given daily subcutaneous injections of 50 mg progesterone or vehicle (sesame oil). After 30 days of treatment, mouse hybridoma cells were transplanted to one… CONTINUE READING

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