Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway

@article{Hsu2008ProgesteroneIH,
  title={Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway},
  author={S.-P. Hsu and P.-Y. Ho and S H Juan and Y. Liang and W. Yong Lee},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={3839-3850}
}
Previous studies have shown that progesterone inhibits endothelial cell proliferation through a nuclear receptor-mediated mechanism. Here, we further demonstrate that progesterone at physiologic levels (5 – 500 nM) dose- and time-dependently inhibited DNA synthesis of cultured human umbilical vein endothelial cells (HUVEC). The mRNA and protein levels of p21, p27, and p53 in HUVEC were increased by progesterone. The formation of CDK2-p21 and CDK2-p27 were increased and the CDK2 activity was… CONTINUE READING