Progesterone inhibits cholesterol biosynthesis in cultured cells. Accumulation of cholesterol precursors.

@article{Metherall1996ProgesteroneIC,
  title={Progesterone inhibits cholesterol biosynthesis in cultured cells. Accumulation of cholesterol precursors.},
  author={James E. Metherall and Kevin Waugh and Hui Li},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 5},
  pages={2627-33}
}
Cells acquire cholesterol through endogenous synthesis and through receptor-mediated uptake of cholesterol-rich low density lipoprotein (LDL). Esterification of LDL-derived cholesterol is catalyzed by acyl-CoA:cholesterol acyltransferase (ACAT) in the endoplasmic reticulum (ER). Progesterone inhibits esterification, and, although the mechanism of inhibition… CONTINUE READING