Progesterone increases nitric oxide synthesis in human vascular endothelial cells through activation of membrane progesterone receptor-α.

@article{Pang2015ProgesteroneIN,
  title={Progesterone increases nitric oxide synthesis in human vascular endothelial cells through activation of membrane progesterone receptor-$\alpha$.},
  author={Y. Pang and J. Dong and P. Thomas},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2015},
  volume={308 10},
  pages={
          E899-911
        }
}
  • Y. Pang, J. Dong, P. Thomas
  • Published 2015
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Progesterone exerts beneficial effects on the human cardiovascular system by inducing rapid increases in nitric oxide (NO) production in vascular endothelial cells, but the receptors mediating these nongenomic progesterone actions remain unclear. Using human umbilical vein endothelial cells (HUVECs) as a model, we show that progesterone binds to plasma membranes of HUVECs with the characteristics of membrane progesterone receptors (mPRs). The selective mPR agonist Org OD 02-0 had high binding… Expand
Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP1 formation.
Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPRα (PAQR7)
Additive effects of low concentrations of estradiol-17β and progesterone on nitric oxide production by human vascular endothelial cells through shared signaling pathways
  • Y. Pang, P. Thomas
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2017
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 76 REFERENCES
Membrane-bound Progesterone Receptor Expression in Human Aortic Endothelial Cells
Estrogen modulation of endothelial nitric oxide synthase.
Nongenomic action of progesterone in rat aorta: role of nitric oxide and prostaglandins.
Progesterone effects on lymphocytes may be mediated by membrane progesterone receptors.
Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells.
Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term.
...
1
2
3
4
5
...