Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells.

@article{Keller2000ProgesteroneEP,
  title={Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells.},
  author={Nancy R. Keller and Elaine Sierra-Rivera and Esther Eisenberg and Kevin G. Osteen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 4},
  pages={
          1611-9
        }
}
Suppression of endometrial matrix metalloproteinases (MMPs) is necessary to maintain tissue stability during the invasive events of implantation and placental development. Several laboratories have shown that inflammatory cytokines, including interleukin-lalpha (IL-1alpha), can oppose progesterone suppression of MMPs in the human endometrium. Furthermore, we have recently demonstrated colocalization of epithelial cell IL-1alpha and MMP-7 expression at sites of ectopic pregnancy. The current… 

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