Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress.

@article{Arck2007ProgesteroneDP,
  title={Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress.},
  author={Petra Clara Arck and Peter J. Hansen and Biserka Mulac Jericevic and M C Piccinni and J{\'u}lia Szekeres-Barth{\'o}},
  journal={American journal of reproductive immunology},
  year={2007},
  volume={58 3},
  pages={268-79}
}
Progesterone is critical for the establishment and the maintenance of pregnancy, both by its endocrine and immunological effects. The genomic actions of progesterone are mediated by the intracellular progesterone receptors; A and B. A protein called P-induced blocking factor (PIBF), by inducing a T(H2) dominant cytokine production, mediates the immunological effects of progesterone. Progesterone plays a role in uterine homing of NK cells and up-regulates HLA-G gene expression, the ligand for… CONTINUE READING
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