Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.

@article{Conneely2003ProgesteronedependentRO,
  title={Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.},
  author={Orla M. Conneely and Biserka Mulac-Jericevic and John P. Lydon},
  journal={Steroids},
  year={2003},
  volume={68 10-13},
  pages={771-8}
}
The steroid hormone, progesterone, is a central coordinator of all aspects of female reproductive activity. The physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed from a single gene as two protein isoforms and that are members of the nuclear receptor superfamily of transcription factors. Analysis of the structural and functional relationships of each isoform using in vitro systems has… CONTINUE READING
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