Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury.

@article{Labombarda2011ProgesteroneAA,
  title={Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury.},
  author={Florencia Labombarda and Susana Laura Gonz{\'a}lez and Anal{\'i}a Lima and Paulina Roig and Rachida Guennoun and Michael Schumacher and Alejandro Federico De Nicola},
  journal={Experimental neurology},
  year={2011},
  volume={231 1},
  pages={135-46}
}
Reactive gliosis, demyelination and proliferation of NG2+ oligodendrocyte precursor cells (OPC) are common responses to spinal cord injury (SCI). We previously reported that short-term progesterone treatment stimulates OPC proliferation whereas chronic treatment enhances OPC differentiation after SCI. Presently, we further studied the proliferation/differentiation of glial cells involved in inflammation and remyelination in male rats with SCI subjected to acute (3 days) or chronic (21 days… CONTINUE READING