Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination

@article{Baulieu2000ProgesteroneAA,
  title={Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination},
  author={E. Baulieu and M. Schumacher},
  journal={Steroids},
  year={2000},
  volume={65},
  pages={605-612}
}
  • E. Baulieu, M. Schumacher
  • Published 2000
  • Biology, Medicine
  • Steroids
  • Some steroids are synthesized within the central and peripheral nervous system, mostly by glial cells. These are known as neurosteroids. In the brain, certain neurosteroids have been shown to act directly on the function of membrane receptors for neurotransmitters. For example, progesterone inhibits the neuronal nicotinic acetylcholine receptor, whereas its 3alpha,5alpha-reduced metabolite 3alpha,5alpha-tetrahydroprogesterone (allopregnanolone) activates the gamma-aminobutyric acid receptor… CONTINUE READING
    94 Citations
    Neuroprotective Actions of Neurosteroids
    • 45
    • PDF
    Neurosteroids; potential underpinning roles in maintaining homeostasis.
    • 6
    Progesterone receptors: Form and function in brain
    • 438
    • PDF
    Nuclear Progesterone Receptors Are Up-Regulated by Estrogens in Neurons and Radial Glial Progenitors in the Brain of Zebrafish
    • 33
    • PDF
    Sex hormones and brain aging
    • 64

    References

    SHOWING 1-10 OF 75 REFERENCES
    Neurosteroids: of the nervous system, by the nervous system, for the nervous system.
    • E. Baulieu
    • Chemistry, Medicine
    • Recent progress in hormone research
    • 1997
    • 617
    Neurosteroids: a new function in the brain.
    • 81
    Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density
    • 166
    • Highly Influential
    • PDF
    Actions of steroid hormones and growth factors on glial cells of the central and peripheral nervous system
    • 94
    • Highly Influential
    Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells.
    • 349
    • Highly Influential
    Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
    • 2,104
    • PDF
    Neurosteroids: Biosynthesis and function
    • 401
    Neurosteroids: pregnenolone in human sciatic nerves.
    • 71
    • PDF