Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination

  title={Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination},
  author={E. Baulieu and M. Schumacher},
  • E. Baulieu, M. Schumacher
  • Published 2000
  • Biology, Medicine
  • Steroids
  • Some steroids are synthesized within the central and peripheral nervous system, mostly by glial cells. These are known as neurosteroids. In the brain, certain neurosteroids have been shown to act directly on the function of membrane receptors for neurotransmitters. For example, progesterone inhibits the neuronal nicotinic acetylcholine receptor, whereas its 3alpha,5alpha-reduced metabolite 3alpha,5alpha-tetrahydroprogesterone (allopregnanolone) activates the gamma-aminobutyric acid receptor… CONTINUE READING
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    Neurosteroids: of the nervous system, by the nervous system, for the nervous system.
    • E. Baulieu
    • Chemistry, Medicine
    • Recent progress in hormone research
    • 1997
    • 617
    Neurosteroids: a new function in the brain.
    • 81
    Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density
    • 166
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    • 2,104
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