Progesterone and the risk of preterm birth among women with a short cervix.

@article{Fonseca2007ProgesteroneAT,
  title={Progesterone and the risk of preterm birth among women with a short cervix.},
  author={Eduardo Borges da Fonseca and Ebru Celık and Mauro Parra and Mandeep Singh and Kypros H. Nicolaides},
  journal={The New England journal of medicine},
  year={2007},
  volume={357 5},
  pages={
          462-9
        }
}
BACKGROUND Previous randomized trials have shown that progesterone administration in women who previously delivered prematurely reduces the risk of recurrent premature delivery. Asymptomatic women found at midgestation to have a short cervix are at greatly increased risk for spontaneous early preterm delivery, and it is unknown whether progesterone reduces this risk in such women. METHODS Cervical length was measured by transvaginal ultrasonography at a median of 22 weeks of gestation (range… Expand
Treatment options and recommendations to reduce preterm births in women with short cervix.
TLDR
Results of the recent PREGNANT trial, consistent with the earlier Fetal Medicine Foundation study, support the use of vaginal progesterone for prevention of preterm birth. Expand
Vaginal Progesterone Pessary for Preterm Labor Prevention in Women with a Short Cervix Early in The Second Trimester
Background The prevention of preterm birth is a major health care priority. Objective To evaluate the efficacy of vaginal progesterone pessary in reducing the rate of preterm delivery and subsequentExpand
Prophylactic progesterone and preterm labor in low-risk twin pregnancies
TLDR
Although vaginal progesterone reduces preterm birth and neonatal complications in singletons with a short cervix, its role in twin pregnancies with a normal cervical length is unclear and needs a larger study to prove its merit. Expand
Preventing preterm birth with progesterone: costs and effects of screening low risk women with a singleton pregnancy for short cervical length, the Triple P study
TLDR
This study will provide evidence for the usefulness and cost-effectiveness of screening for short cervical length at the 18-22 weeks and subsequent progesterone treatment among low risk women. Expand
The prevalence of short cervix between 20 and 24 weeks of gestation and vaginal progesterone for prolonging of gestation
  • Malipati Maerdan, C. Shi, Xiao-xiao Zhang, Lixin Fan
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2017
TLDR
Vaginal progesterone is efficacious for the prolonging of gestation in women with a cervical length of 10–20 mm in the mid-trimester for a singleton gestation and nulliparous women. Expand
Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety
TLDR
Vaginal progesterone administration in asymptomatic twin pregnancies with sonographic short cervix at 20–24 weeks of gestation is effective and safe treatment for reducing the incidence of preterm labor with subsequent reduction in the neonatal morbidities and mortality associated with preterm birth. Expand
Progesterone to prevent miscarriage in women with early pregnancy bleeding: the PRISM RCT.
TLDR
Progesterone therapy in the first trimester of pregnancy did not result in a significantly higher rate of live births among women with threatened miscarriage overall, but an important subgroup effect was identified. Expand
A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth.
TLDR
Among girls and women with singleton pregnancies who had a short cervix, a cervical pessary did not result in a lower rate of spontaneous early preterm delivery than the rate with expectant management. Expand
Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
TLDR
Daily treatment with progesterone gel did not prolong multiple pregnancy compared with placebo, and effective prevention strategies are needed to reduce preterm deliveries among women with multiple gestations. Expand
The effect of postoperative vaginal progesterone in ultrasound-indicated cerclage to prevent preterm birth
  • J. Park, Y. Jung, S. Kook, Se Jeong Jeon, K. Oh, J. Hong
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2019
TLDR
The use of vaginal progesterone was associated with lower rates of preterm birth before 34 and 37 weeks of gestation in women who underwent ultrasound-indicated cerclage placement. Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate
Preterm delivery before 37 completed weeks gestation remains the major factor influencing infant mortality in developed countries. Women who have had a spontaneous preterm delivery are at much higherExpand
The length of the cervix and the risk of spontaneous premature delivery. National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network.
TLDR
The risk of spontaneous preterm delivery is increased in women who are found to have a short cervix by vaginal ultrasonography during pregnancy. Expand
Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.
TLDR
Prophylactic vaginal progesterone reduced the frequency of uterine contractions and the rate of preterm delivery in women at high risk for prematurity in a high-risk population. Expand
Maternal characteristics and cervical length in the prediction of spontaneous early preterm delivery in twins.
TLDR
In twins, the prediction of spontaneous early preterm delivery by measurement of cervical length at 22 to 24 weeks is not improved by maternal characteristics and logistic regression analysis demonstrated that the only significant independent predictor of spontaneousEarly delivery was cervical length. Expand
Prenatal administration of progesterone for preventing preterm birth.
TLDR
Intramuscular progesterone is associated with a reduction in the risk of preterm birth less than 37 weeks' gestation, and infant birthweight less than 2500 grams. Expand
A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins.
TLDR
Treatment with 17 alpha-hydroxyprogesterone caproate did not reduce the rate of preterm birth in women with twin gestations. Expand
The preterm prediction study: effect of gestational age and cause of preterm birth on subsequent obstetric outcome. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.
TLDR
An early prior spontaneous preterm delivery is more predictive of recurrence and is most highly associated with subsequent early spontaneous pre term delivery. Expand
Pharmacokinetics and endometrial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study.
TLDR
Vaginal micronized P enhances P delivery to the uterus compared with a standard IM regimen and results in a synchronous secretory endometrial histology in agonadal women preparing for embryo donation. Expand
Neurologic and developmental disability at six years of age after extremely preterm birth.
TLDR
Among extremely preterm children, cognitive and neurologic impairment is common at school age and a comparison with their classroom peers indicates a level of impairment that is greater than is recognized with the use of standardized norms. Expand
Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration.
TLDR
Low dose micronized progesterone administered vaginally is simple, easy and well tolerated, it could be recommended as the method of choice for luteal support, especially for high responder patients at risk for ovarian hyperstimulation syndrome. Expand
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