Progesterone and progestins modulate beta-endorphin concentrations in the hypothalamus and in the pituitary of castrated female rats.

@article{Genazzani1987ProgesteroneAP,
  title={Progesterone and progestins modulate beta-endorphin concentrations in the hypothalamus and in the pituitary of castrated female rats.},
  author={Andrea Riccardo Genazzani and Felice Petraglia and Marco Bergamaschi and Alessandro David Genazzani and Fabio Facchinetti and Annibale Volpe},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  year={1987},
  volume={1 1},
  pages={
          61-9
        }
}
Hypothalamic and pituitary beta-endorphin (B-EP) concentrations are modified by ovariectomy and estrogen treatments, supporting a direct interaction between this peptidergic system and gonadal steroids. Because the use of progestins is becoming even more diffuse in clinical practice, we evaluated the effect of progesterone and of the synthetic progestins medroxyprogesterone acetate (MPA), norethisterone acetate (NET) and desogestrel on the concentration of B-EP in the medial-basal hypothalamus… CONTINUE READING