Progesterone and progestins: applications in gynecology

@article{Ziegler2000ProgesteroneAP,
  title={Progesterone and progestins: applications in gynecology},
  author={Dominique de Ziegler and R{\'e}nato Fanchin},
  journal={Steroids},
  year={2000},
  volume={65},
  pages={671-679}
}
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It is demonstrated that vaginally administered progesterone could reach levels that are similar to those obtained in ovulatory and luteal phases, and the progestersone regimen for adequate endometrial protection and in vitro fertilization (IVF) programs still remains to be studied.

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After estrogen endometrial priming in POF patients, exogenous vaginal micronized progesterone is more effective than oral DG in creating an 'in-phase' secretory endometrium and induces significantly higher progester one and lower LH and FSH serum concentrations on day 21 of the cycle.

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Current data suggest no difference in outcome between hormonally medicated protocols or natural cycles and that no benefit is gained by adding progesterone to the luteal phase of modified natural treatment cycles, so additional research is needed to inform the decision-making process.

Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support.

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Vaginal administration of E2 and DG is more effective than oral administration regarding proliferative and secretory transformation of the endometrium in POF patients and preparing for assisted reproductive technology.

Metabolism of endogenous and exogenous reproductive hormones.

  • D. Grow
  • Medicine, Biology
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  • 2002

Oral dydrogesterone for luteal phase support in fresh in vitro fertilization cycles: a new standard?

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It was concluded that the vaginal route for administering micronized progesterone can be advised as the treatment of choice in patients without ovarian function.

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