Progesterone and progestins: applications in gynecology

@article{Ziegler2000ProgesteroneAP,
  title={Progesterone and progestins: applications in gynecology},
  author={D. Ziegler and R. Fanchin},
  journal={Steroids},
  year={2000},
  volume={65},
  pages={671-679}
}
Achievements obtained in infertility treatments over the past two decades have sparked interest in optimizing progesterone administration. Although progesterone is absorbed orally when ingested in micronized form, bioavailability is poor because of extensive liver metabolism. This explains why full predecidual transformation of the endometrium cannot be achieved with oral progesterone and is therefore ineffective for luteal support in in vitro fertilization (IVF). Progesterone administered non… Expand
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Interventional Clinical Trial
Endometrial Effects of Daily Progesterone s.c. 25 and 50 Mg Aqueous Formulation to Female Healthy Volunteers
This is a multiple dose, observer blind, randomised, parallel groups pharmacodynamic and pharmacokinetic study to assess the endometrial effects (predecidual changes) of a new… Expand
ConditionsHealthy
InterventionDrug
IBSA Institut Biochimique SA
August 2005 - March 2006

42 Citations

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  • Medicine
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Oral dydrogesterone for luteal phase support in fresh in vitro fertilization cycles: a new standard?
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