Progesterone and progestins: applications in gynecology

  title={Progesterone and progestins: applications in gynecology},
  author={Dominique de Ziegler and R{\'e}nato Fanchin},

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Pharmacokinetics of Natural Progesterone Vaginal Suppository

It is demonstrated that vaginally administered progesterone could reach levels that are similar to those obtained in ovulatory and luteal phases, and the progestersone regimen for adequate endometrial protection and in vitro fertilization (IVF) programs still remains to be studied.

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Effect of oral administration of dydrogestrone versus vaginal administration of natural micronized progesterone on the secretory transformation of endometrium and luteal endocrine profile in patients with premature ovarian failure: a proof of concept.

After estrogen endometrial priming in POF patients, exogenous vaginal micronized progesterone is more effective than oral DG in creating an 'in-phase' secretory endometrium and induces significantly higher progester one and lower LH and FSH serum concentrations on day 21 of the cycle.

A Review of Luteal Support Protocols for Single Embryo Transfers: Fresh and Frozen

Current data suggest no difference in outcome between hormonally medicated protocols or natural cycles and that no benefit is gained by adding progesterone to the luteal phase of modified natural treatment cycles, so additional research is needed to inform the decision-making process.

Effect of Oral versus Vaginal Administration of Estradiol and Dydrogesterone on the Proliferative and Secretory Transformation of Endometrium in Patients with Premature Ovarian Failure and Preparing for Assisted Reproductive Technology

Vaginal administration of E2 and DG is more effective than oral administration regarding proliferative and secretory transformation of the endometrium in POF patients and preparing for assisted reproductive technology.

Metabolism of endogenous and exogenous reproductive hormones.

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New hormonal therapies and regimens in the postmenopause: routes of administration and timing of initiation

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The combination of non-oral administration of estradiol and local delivery of progesterone or a progestin such as levonorgestrel by means of gels, sprays, vaginal rings or intrauterine systems would represent new methods of replacement therapy for the menopausal woman, improving compliance and minimizing the risks of hormone replacement.



Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure.

It was concluded that the vaginal route for administering micronized progesterone can be advised as the treatment of choice in patients without ovarian function.

Uses of progesterone in clinical practice.

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Studies in infertility show that vaginal progesterone in this form allows secretory transformation of the endometrium and the development of pregnancy despite providing low systemic progestersone concentrations, and fewer side effects occur when used for hormone replacement than typically encountered with progestins and oral progestone.

Vaginal progesterone in menopause: Crinone 4% in cyclical and constant combined regimens.

The results indicate that both regimens using the sustained release vaginal progesterone gel controlled bleeding in HRT, combined with the lower incidence of side-effects characteristic of vaginal progestone, both vaginal progestersone regimens have the potential of improving HRT compliance.

Effects of luteal estradiol on the secretory transformation of human endometrium and plasma gonadotropins.

In women deprived of ovarian function, administration of P only after 14 days of E2 priming prevented uterine bleeding and induced normal secretory transformations of the endometrium, but failed to suppress plasma gonadotropins.

The hormonal control of endometrial receptivity: estrogen (E2) and progesterone.