Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification.

@article{Li2003ProgesteroneAG,
  title={Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification.},
  author={Xiaotao Li and Jiemin Wong and Sophia Y. Tsai and Ming-jer Tsai and Bert W O'malley},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 11},
  pages={3763-73}
}
It is well established that steroid receptor function requires interaction with coactivators. However, the mechanisms through which steroid receptors elicit precise assembly of coactivator complexes and the way the steroid activation signal is transduced remain elusive. Using a T47D cell line stably integrated with a mouse mammary tumor virus-chloramphenicol acetyltransferase (MMTV-CAT) reporter, we demonstrate that specific steroid receptors exhibit preferential recruitment of SRC-1 family… CONTINUE READING
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