Progesterone and conceptus elongation in cattle: a direct effect on the embryo or an indirect effect via the endometrium?

@article{Clemente2009ProgesteroneAC,
  title={Progesterone and conceptus elongation in cattle: a direct effect on the embryo or an indirect effect via the endometrium?},
  author={M. Clemente and Julio de la Fuente and Trudee Fair and Abdullah al Naib and Alfonso Guti{\'e}rrez-Ad{\'a}n and James F. Roche and Dimitrios Rizos and Pat Lonergan},
  journal={Reproduction},
  year={2009},
  volume={138 3},
  pages={
          507-17
        }
}
The steroid hormone progesterone (P(4)) plays a key role in the reproductive events associated with pregnancy establishment and maintenance. High concentrations of circulating P(4) in the immediate post-conception period have been associated with an advancement of conceptus elongation, an associated increase in interferon-tau production and higher pregnancy rates in cattle. Using in vitro and in vivo models and approximately 8500 bovine oocytes across six experiments, the aim of this study was… Expand
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A combination of in vivo and in vitro experiments found that the effects of P4 on conceptus elongation are indirect and mediated through P4-induced effects in the endometrium. Expand
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Recent findings from this group and others in relation to embryo-maternal interaction during bovine pregnancy establishment and the role of P4 in uterine biology and embryo development are highlighted. Expand
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Recent knowledge on the effect of P4 on conceptus development in cattle is reviewed and strategies that have been undertaken to manipulate post fertilization P4 concentrations to increase fertility are summarized. Expand
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Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle.
  • P. Lonergan, N. Forde
  • Medicine, Biology
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  • 2014
TLDR
This review summarizes current knowledge on the communication between the developing embryo and the maternal reproductive tract and indicates that Progesterone plays a key role in reproductive events associated with establishment and maintenance of pregnancy through its action on the uterine endometrium. Expand
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The Role of Progesterone in Maternal Recognition of Pregnancy in Domestic Ruminants.
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Recent data on the role of P4 in conceptus development in ruminants, particularly cattle, are reviewed and results from attempts at manipulating endogenous P4 with the aim of improving conceptus survival and pregnancy rate are summarized. Expand
Effect of Elevated Circulating Progesterone Concentration on Bovine Blastocyst Development and Global Transcriptome Following Endoscopic Transfer of In Vitro Produced Embryos to the Bovine Oviduct1
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Establishment of critical timing of progesterone supplementation on corpus luteum and embryo development in beef heifers.
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The results of the study indicate an initiation and duration effect of supplemental P4 on circulating P4, embryo and CL development following induction of LP4 on Day 3 and 4. Expand
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