Progesterone activates the principal Ca2+ channel of human sperm

  title={Progesterone activates the principal Ca2+ channel of human sperm},
  author={P. Lishko and I. Botchkina and Yuriy Kirichok},
  • P. Lishko, I. Botchkina, Yuriy Kirichok
  • Published 2011
  • Biology, Medicine
  • Nature
  • Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them penetrate the egg’s protective vestments. Progesterone induces Ca2+ influx into spermatozoa and triggers multiple Ca2+-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the egg. As an ovarian hormone, progesterone acts by… CONTINUE READING
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