Progesterone activates the principal Ca2+ channel of human sperm
@article{Lishko2011ProgesteroneAT, title={Progesterone activates the principal Ca2+ channel of human sperm}, author={P. Lishko and I. Botchkina and Yuriy Kirichok}, journal={Nature}, year={2011}, volume={471}, pages={387-391} }
Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them penetrate the egg’s protective vestments. Progesterone induces Ca2+ influx into spermatozoa and triggers multiple Ca2+-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the egg. As an ovarian hormone, progesterone acts by… CONTINUE READING
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References
SHOWING 1-10 OF 33 REFERENCES
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
- Biology, Medicine
- Nature
- 2011
- 414
A new prostaglandin E receptor mediates calcium influx and acrosome reaction in human spermatozoa.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1998
- 80
- PDF
Nongenomic activation of spermatozoa by steroid hormones: Facts and fictions
- Biology, Medicine
- Molecular and Cellular Endocrinology
- 2009
- 134
- PDF
Prostaglandins induce calcium influx in human spermatozoa.
- Biology, Medicine
- Molecular human reproduction
- 1998
- 35
- PDF
Stimulation of Human Spermatozoa with Progesterone Gradients to Simulate Approach to the Oocyte
- Biology, Medicine
- Journal of Biological Chemistry
- 2004
- 165
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
- Biology, Medicine
- Nature
- 2006
- 332
- PDF
Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel
- Biology, Medicine
- Cell
- 2010
- 259
Egg Coat Proteins Activate Calcium Entry into Mouse Sperm via CATSPER Channels1
- Biology, Medicine
- Biology of reproduction
- 2009
- 63
- PDF
Non-genomic progesterone actions in female reproduction.
- Biology, Medicine
- Human reproduction update
- 2009
- 169
- PDF
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2007
- 391
- PDF