Progesterone activates the principal Ca2+ channel of human sperm

@article{Lishko2011ProgesteroneAT,
  title={Progesterone activates the principal Ca2+ channel of human sperm},
  author={Polina V. Lishko and Inna L. Botchkina and Yuriy Kirichok},
  journal={Nature},
  year={2011},
  volume={471},
  pages={387-391}
}
Steroid hormone progesterone released by cumulus cells surrounding the egg is a potent stimulator of human spermatozoa. It attracts spermatozoa towards the egg and helps them penetrate the egg’s protective vestments. Progesterone induces Ca2+ influx into spermatozoa and triggers multiple Ca2+-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the egg. As an ovarian hormone, progesterone acts by… 
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It is found that both progesterone and alkaline pH stimulate a rapid Ca2+ influx with almost no latency, incompatible with a signalling pathway involving metabotropic receptors and second messengers.
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TLDR
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