Progesterone Receptor A and B Isoforms in the Human Breast and Its Disorders

  title={Progesterone Receptor A and B Isoforms in the Human Breast and Its Disorders},
  author={Naohiro Ariga and Takashi Suzuki and Takuya Moriya and Michio Kimura and Tsukasa Inoue and Noriaki Ohuchi and Hironobu Sasano},
  booktitle={Japanese journal of cancer research : Gann},
Two different isoforms of progesterone receptor (PR), PRA and PRB, are expressed in target tissues at comparable levels. In this study, we first examined PRA and PRB immunoreactivity in human breast cancer and various intraductal proliferative epithelial lesions, and correlated these findings with clinicopathologic parameters. We then examined mRNA expression of PRA and PRB in six cases of invasive ductal carcinoma using RT-PCR. Immunoreactivity for both PRA and PRB was positive in the great… CONTINUE READING
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