Progesterone Is Important for Transgender Women’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen

@article{Prior2019ProgesteroneII,
  title={Progesterone Is Important for Transgender Women’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen},
  author={J. Prior},
  journal={The Journal of Clinical Endocrinology \& Metabolism},
  year={2019},
  volume={104},
  pages={1181–1186}
}
  • J. Prior
  • Published 2019
  • Medicine
  • The Journal of Clinical Endocrinology & Metabolism
BACKGROUND Although the 2017 Endocrine Society Guidelines for gender dysphoria stipulated that cross-sex hormone therapy (CHT) achieve gonadal steroid levels equivalent to those of a cisperson of the chosen sex, for transgender women (male-to-female gender dysphoria), current gonadal therapy is usually estradiol. Accumulated evidence indicates that normally ovulatory menstrual cycles are necessary for ciswomen's current fertility, as well as for later-life bone and cardiovascular health and the… Expand
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TLDR
Reference intervals specific to transgender women should be applied when evaluating reproductive endocrine analytes related to reproductive endocrinology in a cohort of healthy gender nonconforming individuals on stable feminizing hormone therapy. Expand
Unmasked Testicular Seminoma During Use of Hormonal Transgender Woman Therapy: A Hidden hCG-Secreting Tumor.
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Testing revealed an elevated serum level of the beta subunit of human chorionic gonadotropin (β-hCG), diagnostic of an hCG-secreting testicular seminoma, as the underlying cause of unexpected T production, illustrating how easily a testicular cancer can remain unnoticed. Expand
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T and E2 therapy are usually effective without progestin or GnRHa therapy to suppress gonadal function in transgender patients and should only be initiated in those patients who do not have adequate gonadal suppression on optimized doses of T or E2 alone. Expand
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The use of hormonal and non-hormonal compounds are suggested, which—based on their mechanism of action—could be used in these cases depending on clients’ requests. Expand
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This narrative review aims to comprehensively summarize health considerations for transgender (trans) women and identify TW-related research areas that will provide answers to remaining unknowns surrounding TW’s health. Expand
IDEA Group Consensus Statement on Medical Management of Adult Gender Incongruent Individuals Seeking Gender Reaffirmation as Female
TLDR
This consensus statement on medical management provides protocols for the prescribing clinician relating to diagnosis, baseline evaluation and counselling, prescription planning for feminizing hormone therapy and anti-androgen therapy, targets for monitoring hormone therapy, choice of therapy, clinical and biochemical monitoring, recommending sex reaffirmation surgery and peri-operative hormone therapy. Expand
Lactation Induction in a Transgender Woman Wanting to Breastfeed: Case Report.
TLDR
This article summarizes a case of successful lactation in a trans woman, in which milk production was achieved in just over 1 month, the second case in the medical literature to demonstrate successful breastfeeding in atrans woman through use of hormonal augmentation. Expand
[Transsexualism and transgender medicine - what every internal specialist should know about].
TLDR
Hormonal therapy is a very important element of the treatment process; due to the complexity of transsexualism it should be undertaken by endocrinologists with experience and expertise in this field. Expand
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An overview of current best practices for culturally sensitive working with transgender patients, and an introduction to the additional considerations for assessment of disease risk in transgender people are provided. Expand
Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)
This review summarizes the current opinions on the mechanisms of action of nuclear, mitochondrial, and membrane progesterone receptors. The main aspects of the pharmacological action of progestins… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
Oestrogen and anti-androgen therapy for transgender women.
TLDR
The evidence base for the care of transgender women is limited by the paucity of high-quality research, and long-term longitudinal studies are needed to inform future guidelines. Expand
Clinical review: Breast development in trans women receiving cross-sex hormones.
TLDR
The available evidence suggests that breast development is insufficient for the majority of trans women and that type and dosage of hormonal therapy seem not to have an important role on final breast size. Expand
Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy
TLDR
Cross-sex hormone therapy (CSHT), particularly with testosterone, is associated with worsening cardiovascular risk factors in transgender men but not with increases in cardiovascular morbidity or mortality, and the literature regarding the association between CSHT and CVD in transgender adults is summarized. Expand
Low estrogen doses normalize testosterone and estradiol levels to the female range in transgender women
TLDR
In this sample of transgender women, lower estrogen doses than those usually prescribed for these subjects were able to adjust the testosterone and estradiol levels to the physiological female range, thus avoiding high estrogen doses and their multiple associated side effects. Expand
Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons.
TLDR
Prospective studies suggest interventions related to hormones, surgery, or both are associated with improved psychological functioning and reduction in anxiety and depression in transgender people. Expand
Breast Development in Transwomen After 1 Year of Cross-Sex Hormone Therapy: Results of a Prospective Multicenter Study
TLDR
It is shown that, after 1 year of CHT, breast development is modest and occurs primarily in the first 6 months, and no clinical or laboratory parameters were found that predict breast development. Expand
Progesterone for treatment of symptomatic menopausal women
  • J. Prior
  • Medicine
  • Climacteric : the journal of the International Menopause Society
  • 2018
TLDR
Evidence is highlighted that oral micronized progesterone (progesterone) is effective for hot flushes and night sweats, improves sleep and is likely safe in menopausal women (who are more than 1 year since last menstruation). Expand
Spironolactone with physiological female steroids for presurgical therapy of male-to-female transsexualism
The clinical and hormonal response to 12-month therapy with the antiandrogen, spironolactone, in conjunction with near-physiologic doses of female gonadal steroids in 50 transsexual males, is… Expand
Cardiovascular disease in transsexual persons treated with cross-sex hormones: reversal of the traditional sex difference in cardiovascular disease pattern.
TLDR
MtoF should not be treated with oral ethinyl estradiol, and transdermal estrogens are probably safer than oral estrogens, and pre-existing cardiovascular risks should be taken into consideration when prescribing and choosing the type of estrogens in cross-sex hormone administration (oral vs transDermal). Expand
Endocrine Treatment of Gender‐Dysphoric/Gender‐Incongruent Persons: An Endocrine Society* Clinical Practice Guideline
TLDR
This evidence‐based guideline recommends treating gender‐dysphoric/gender‐incongruent adolescents who have entered puberty at Tanner Stage G2/B2 by suppression with gonadotropin‐releasing hormone agonists and recommends adding gender‐affirming hormones after a multidisciplinary team has confirmed the persistence of gender dysphoria/gender incongruence. Expand
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