Progesterone Is Important for Transgender Women’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen

@article{Prior2019ProgesteroneII,
  title={Progesterone Is Important for Transgender Women’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen},
  author={Jerilynn C. Prior},
  journal={The Journal of Clinical Endocrinology \& Metabolism},
  year={2019},
  volume={104},
  pages={1181–1186}
}
  • J. Prior
  • Published 2019
  • Medicine
  • The Journal of Clinical Endocrinology & Metabolism
BACKGROUND Although the 2017 Endocrine Society Guidelines for gender dysphoria stipulated that cross-sex hormone therapy (CHT) achieve gonadal steroid levels equivalent to those of a cisperson of the chosen sex, for transgender women (male-to-female gender dysphoria), current gonadal therapy is usually estradiol. Accumulated evidence indicates that normally ovulatory menstrual cycles are necessary for ciswomen's current fertility, as well as for later-life bone and cardiovascular health and the… Expand
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Citation Type

Reproductive Endocrinology Reference Intervals for Transgender Women on Stable Hormone Therapy.
TLDR
Reference intervals specific to transgender women should be applied when evaluating reproductive endocrine analytes related to reproductive endocrinology in a cohort of healthy gender nonconforming individuals on stable feminizing hormone therapy. Expand
Unmasked Testicular Seminoma During Use of Hormonal Transgender Woman Therapy: A Hidden hCG-Secreting Tumor.
TLDR
Testing revealed an elevated serum level of the beta subunit of human chorionic gonadotropin (β-hCG), diagnostic of an hCG-secreting testicular seminoma, as the underlying cause of unexpected T production, illustrating how easily a testicular cancer can remain unnoticed. Expand
A REVIEW OF BREAST DEVELOPMENT IN CISGENDER WOMEN AND IMPLICATIONS FOR TRANSGENDER WOMEN.
  • Tamar Reisman, Zil G Goldstein, J. Safer
  • Medicine
  • Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2019
TLDR
The objective of this article is to describe the hormonal pathways required for breast development in cisgender women and to review the current available literature describing breast growth and breast cancer risk in transgender women. Expand
Efficacy of Sex Steroid Therapy without Progestin or GnRH Agonist for Gonadal Suppression in Adult Transgender Patients.
TLDR
T and E2 therapy are usually effective without progestin or GnRHa therapy to suppress gonadal function in transgender patients and should only be initiated in those patients who do not have adequate gonadal suppression on optimized doses of T or E2 alone. Expand
Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals
TLDR
The use of hormonal and non-hormonal compounds are suggested, which—based on their mechanism of action—could be used in these cases depending on clients’ requests. Expand
Health considerations for transgender women and remaining unknowns: a narrative review
TLDR
This narrative review aims to comprehensively summarize health considerations for transgender (trans) women and identify TW-related research areas that will provide answers to remaining unknowns surrounding TW’s health. Expand
IDEA Group Consensus Statement on Medical Management of Adult Gender Incongruent Individuals Seeking Gender Reaffirmation as Female
TLDR
This consensus statement on medical management provides protocols for the prescribing clinician relating to diagnosis, baseline evaluation and counselling, prescription planning for feminizing hormone therapy and anti-androgen therapy, targets for monitoring hormone therapy, choice of therapy, clinical and biochemical monitoring, recommending sex reaffirmation surgery and peri-operative hormone therapy. Expand
Lactation Induction in a Transgender Woman Wanting to Breastfeed: Case Report.
TLDR
This article summarizes a case of successful lactation in a trans woman, in which milk production was achieved in just over 1 month, the second case in the medical literature to demonstrate successful breastfeeding in atrans woman through use of hormonal augmentation. Expand
[Transsexualism and transgender medicine - what every internal specialist should know about].
TLDR
Hormonal therapy is a very important element of the treatment process; due to the complexity of transsexualism it should be undertaken by endocrinologists with experience and expertise in this field. Expand
Considerations in genetic counseling of transgender patients: Cultural competencies and altered disease risk profiles
TLDR
An overview of current best practices for culturally sensitive working with transgender patients, and an introduction to the additional considerations for assessment of disease risk in transgender people are provided. Expand
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