Progesterone Inhibits Female-Typical Receptive Behavior and Decreases Hypothalamic Estrogen and Progesterone Receptor Messenger Ribonucleic Acid Levels in Whiptail Lizards (GenusCnemidophorus)

@article{Godwin1996ProgesteroneIF,
  title={Progesterone Inhibits Female-Typical Receptive Behavior and Decreases Hypothalamic Estrogen and Progesterone Receptor Messenger Ribonucleic Acid Levels in Whiptail Lizards (GenusCnemidophorus)},
  author={John R Godwin and Vesta Hartman and Michael G. Grammer and David Crews},
  journal={Hormones and Behavior},
  year={1996},
  volume={30},
  pages={138-144}
}
Female-typical sexual behavior in tetrapods is mediated primarily by estrogen and progesterone acting through intracellular receptors at specific sites in the mediobasal hypothalamus. Progesterone exerts both faciliatory and inhibitory actions on female sexual behavior and in well-studied rodent models, the inhibitory actions are exerted through downregulation of progesterone and estrogen receptors. This study examined progesterone effects on both female-typical sexual behavior and hypothalamic… 
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Intrahypothalamic Implantation of Progesterone in Castrated Male Whiptail Lizards (Cnemidophorus inornatus) Elicits Courtship and Copulatory Behavior and Affects Androgen Receptor- and Progesterone Receptor-mRNA Expression in the Brain
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Progesterone differentially regulates its own receptor as well as androgen receptor in areas of the brain involved in the control of sexual behavior of males and that the nature of this regulation shows individual variability.
Effect of Long-Term Castration and Long-Term Androgen Treatment on Sexually Dimorphic Estrogen-Inducible Progesterone Receptor mRNA Levels in the Ventromedial Hypothalamus of Whiptail Lizards
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Long-term castration in male whiptail lizards increases sensitivity to estradiol as measured by induction of PR mRNA in the VMH, but long-term androgenization did not attenuate the estrogen response in females, suggesting that attenuation of theosterone response in males requires activation by testicular secretions, but that females cannot be made to show a male phenotype via testosterone administration.
Hormonal regulation of progesterone receptor mRNA expression in the hypothalamus of whiptail lizards: regional and species differences.
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It is reported that exogenous estrogen increases progesterone receptor (PR) mRNA levels in the periventricular preoptic area in an ancestor and descendant species pair of whiptail lizards, and also that this effect of estrogen is significantly stronger in females of the descendant species.
Molecular characterization and brain distribution of the progesterone receptor in whiptail lizards.
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The increase in PR-ir staining intensity in AR-ir neurons in courting birds suggests that this progesterone-dependent termination of aggressive courtship display in males occurs at the receptor level and may be orchestrated by central oestrogen.
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Examining how various environmental chemicals may interrupt normal organizational and activational events in poikilothermic vertebrates finds that NED disrupt normal organizational-activational effects of endogenous hormones, although it remains to be determined if these disturbances are reversible.
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