Progesterone 5-α-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes

@article{Melcangi1994Progesterone5I,
  title={Progesterone 5-α-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes},
  author={R. Melcangi and F. Celotti and L. Martini},
  journal={Brain Research},
  year={1994},
  volume={639},
  pages={202-206}
}
  • R. Melcangi, F. Celotti, L. Martini
  • Published 1994
  • Biology, Medicine
  • Brain Research
  • Progesterone, like testosterone, can be converted in the brain into 5-alpha-reduced metabolites (5-alpha-pregnan-3,20-dione, DHP; 5-alpha-pregnan-3-alpha-ol-20-one, THP). Recently we have shown that testosterone is 5-alpha-reduced to DHT mainly in neurons, while glial cells possess this enzymatic activity only in limited amounts. On the other hand, a glial cell type (type 1 astrocytes) is almost exclusively responsible for the further metabolism of DHT into 3-alpha-diol. The aim of the present… CONTINUE READING
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