Progesterone: a critical role in the pathogenesis of uterine myomas.

@article{Rein1995ProgesteroneAC,
  title={Progesterone: a critical role in the pathogenesis of uterine myomas.},
  author={Mitchell Rein and Robert L. Barbieri and Andrew Friedman},
  journal={American journal of obstetrics and gynecology},
  year={1995},
  volume={172 1 Pt 1},
  pages={
          14-8
        }
}
Uterine leiomyomas are monoclonal tumors. However, the factors involved in their initiation and growth remain poorly understood. The neoplastic transformation of myometrium to leiomyoma likely involves somatic mutations of normal myometrium and the complex interactions of sex steroids and local growth factors. Traditionally, estrogen has been considered the major promoter of myoma growth. The purpose of this review is to highlight the biochemical, histologic, and clinical evidence that supports… CONTINUE READING
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