Progesterone/RANKL is a major regulatory axis in the human breast.

  title={Progesterone/RANKL is a major regulatory axis in the human breast.},
  author={Tamara Tanos and George Sflomos and Pablo C. Echeverr{\'i}a and Ayyakkannu Ayyanan and Mar{\'i}a Nelly Guti{\'e}rrez and Jean-François Delaloye and Wassim Raffoul and Maryse Fiche and William C. Dougall and Pascal Schneider and Ozden Yalcin-Ozuysal and Cathrin Brisken},
  journal={Science translational medicine},
  volume={5 182},
Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor κB ligand (RANKL) has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis. Whether the factor has the same role in humans is of clinical interest because an… CONTINUE READING