Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma.

@article{Smith2007ProgesteroneGB,
  title={Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma.},
  author={Robert Anthony Smith and Rod A. Lea and Stephen R. Weinstein and Lyn R Griffiths},
  journal={Cancer letters},
  year={2007},
  volume={255 1},
  pages={77-84}
}
Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk using hormone signaling in these tissues. RNA levels in stromal tissue were examined for the estrogen alpha, estrogen beta, androgen, progesterone and glucocorticoid nuclear receptors by a semi-quantitative PCR. Significant differences in expression between the cancer stroma and control tissue were… CONTINUE READING