Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases.

@article{Mehra2006ProgenitorMC,
  title={Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases.},
  author={Niven Mehra and Maarten T. Penning and Jolanda Maas and Laurens Victor Beerepoot and Nancy van Daal and Carla H van Gils and Rachel H Giles and Emile E Voest},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 16},
  pages={4859-66}
}
PURPOSE We examined whether RNA expression of CD133, a surface molecule expressed on progenitors from hematopoietic and endothelial lineages, and CD146, a pan-endothelial marker, are increased in the blood of cancer patients and whether these factors correlate with patient characteristics and are predictive factors of survival. EXPERIMENTAL DESIGN We developed a real-time quantification method (nuclear acid sequence-based amplification) to determine expression of CD146 and CD133 mRNA in the… CONTINUE READING