Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.

@article{Huang2010ProgenitorCE,
  title={Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.},
  author={Chen-Che Huang and Shinichi Miyagawa and Daisuke Matsumaru and Keith L. Parker and Humphrey Hung-Chang Yao},
  journal={Endocrinology},
  year={2010},
  volume={151 3},
  pages={1119-28}
}
The adrenal capsule is postulated to harbor stem/progenitor cells, the progenies of which contribute to the growth of adrenocortex. We discovered that cells in the adrenal capsule are positive for Ptch1 and Gli1, genes indicative of responsiveness to the stimulation of Hedgehog (Hh) ligands. On the other hand, Sonic hedgehog (Shh), one of the mammalian Hh ligands, is expressed in the adrenocortex underneath the adrenal capsule, possibly acting upon the Hh-Responsive capsule. To investigate the… CONTINUE READING