Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis.

@article{Dubuquoy2015ProgenitorCE,
  title={Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis.},
  author={Laurent Dubuquoy and Alexandre Louvet and Guillaume Lassailly and St{\'e}phanie Truant and E Boleslawski and Florent Artru and François Maggiotto and Emilie Gantier and David Buob and Emmanuelle A Leteurtre and Am{\'e}lie Cannesson and S{\'e}bastien Dharancy and Christophe Moreno and F R Pruvot and Ram{\'o}n Bataller and Philippe Mathurin},
  journal={Gut},
  year={2015},
  volume={64 12},
  pages={1949-60}
}
OBJECTIVE In alcoholic hepatitis (AH), development of targeted therapies is crucial and requires improved knowledge of cellular and molecular drivers in liver dysfunction. The unique opportunity of using explanted livers from patients with AH having undergone salvage liver transplantation allowed to perform more in-depth molecular translational studies. DESIGN We studied liver explants from patients with AH submitted to salvage transplantation (n=16), from patients with alcoholic cirrhosis… CONTINUE READING

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