Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling.

@article{Tang2008ProgenitorstemCG,
  title={Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling.},
  author={Yi Tang and Krit Kitisin and Wilma S. Jogunoori and Cuiling Li and Chu-xia Deng and Susette C. Mueller and Habtom W. Ressom and Asif Rashid and Aiwu Ruth He and Jonathan S Mendelson and J. Milburn. Jessup and Kirti Shetty and Michael Zasloff and Bibhuti Mishra and E. P. Reddy and Lynt Johnson and Lopa Mishra},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 7},
  pages={2445-50}
}
Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between specific signaling pathways in solid organ "cancer stem cells," such as those of the liver, remain elusive. We report that in regenerating human liver, two to four cells per 30,000-50,000 cells express stem… CONTINUE READING